Specialty pharmaceuticals manufacturing can often be best controlled at very low temperatures to minimize the formation of undesirable by-products that could lead to problem side effects, yield losses, and increased processing costs. Eastman Therminol® liquid-phase heat transfer fluids include the lowest-temperature-rated organic heat transfer fluid available, specifically formulated to meet these chiral process requirements at temperatures unmatched by other fluids. This application requires the use of an appropriate chiller to remove the process heat from the heat transfer fluid (coolant), which can provide superior temperature control to processes compared to gas cooling alternatives.